Why do we need weight loss FDA approval solid liraglutide intermediates?

As we all know, in the pharmaceutical industry, the production of preparations needs to be supported by the API links upstream of the industry chain. It can be seen that the large demand for liraglutide injection will inevitably drive the growth of the demand for its APIs. The liraglutide bulk drug market will be greatly expanded.

What is the relationship between liraglutide and adiponectin?

Why do we need liraglutide so much?

How does liraglutide work?

What is the relationship between liraglutide and adiponectin?

Obesity has become a global human health crisis. Abnormalities such as fat accumulation in muscles and insulin resistance can be detected in the body at the earliest, and there is a risk of developing type 2 diabetes, hypertension, and other cardiovascular diseases. Obesity reduces the level of serum adiponectin, and hypoadiponectinemia can lead to insulin resistance. The level of adiponectin rises with the decrease of BMI. liraglutide can lower the body's BMI. There is no clear conclusion about whether there is a connection between the two. In the study of mice, it was found that liraglutide may increase the level of serum adiponectin, improve glucose and lipid metabolism, and thereby increase the sensitivity of the body's insulin, but its specific mechanism and links need to be further studied, liraglutide Whether there is the same relationship with human serum adiponectin levels has not been reported.

Why do we need liraglutide so much?

Diabetes has become an important public health problem, and the prevention and treatment of diabetes are very important. There is an endless stream of hypoglycemic drugs on the market, and most hypoglycemic drugs have the risk of causing hypoglycemia. As a new type of hypoglycemic drug, liraglutide has its unique mechanism of action.

The risk of hypoglycemia is low, but the safety and effectiveness of long-term application still need more evidence-based medical evidence. As a protective factor of the body, adiponectin is more beneficial to people's health by increasing the level of adiponectin. If liraglutide can increase the level of human serum adiponectin, it will have a broader prospect. However, the difference between the two The relationship and the specific mechanism of action need to be further studied.

How does liraglutide work?

Pancreatic β-cell failure is the core of the pathogenesis of diabetes. Studies have found that glucotoxicity and lipotoxicity are the main pathological mechanisms that lead to the impairment of β-cell function. At the same time, research

The study also found that liraglutide can improve the function of pancreatic β-cells. The role of glucagon-like peptide I to improve blood sugar is not only to regulate insulin secretion but more importantly, to regulate β cell function, by promoting β cell regeneration and secretion, reducing β cell apoptosis, and increasing the number of β cells. Studies have found that liraglutide can significantly improve the level of one-phase and two-phase insulin in patients with type 2 diabetes. In vitro studies have shown that liraglutide can counteract the inhibitory effect of low-density lipoprotein on the proliferation of pancreatic β-cells, and inhibit the apoptosis of β-cells induced by leukocyte mediator 1, and promote β-cell proliferation.

With the increasing number of diabetic patients worldwide, the efficacy of liraglutide for diabetes has been paid more and more attention. liraglutide produced by Chengdu Pukang Company is a high-quality raw material with high purity. Contact Chengdu Pukang Company for more detailed information.