+86-13708084407
  export@pu-kang.com            lorena@pu-kang.com
 
SNAC-

SNAC Semaglutide Tablets Absorption Enhancer

SNAC is the absorption enhancer of semaglutide tablets. It is an N-acetylated amino acid derivative synthesized from salicylic acid, which is weakly acidic and amphiphilic. 
SNAC is the only penetration enhancer approved to improve oral absorption. In other preclinical studies, SNAC has the effect of improving the penetration of peptides (such as insulin) in the intestine. 
Semaglutide tablets containing SNAC are placed in different volumes of simulated gastric juice, and the pH value gradually changes from acidic to neutral. The smaller the volume, the more obvious the buffering effect; on the contrary, the SNAC-free Semaglutide tablets have no significant effect on the pH value of simulated gastric juice .In view of the significant buffering effect of SNAC, the effect of pH on the stability of semaglutide was investigated in in the presence of pepsin.
As the SNAC Manufacturer, we Chengdu Pukang can provide the high purity product.

Advanced SNAC Excipients Mechanism

 
Refer to SNAC excipients mechanism, we have some research. Semaglutide molecules are amphiphilic, and they can combine with each other through hydrophobic interactions to form oligomers. After semaglutide tablets are dissolved, SNAC the powder one can cause a change in the polarity of the solution and weaken the hydrophobic interaction between molecules. SNAC is lipophilic and can be effectively inserted into the upper cortical membrane of the stomach, which is penetration enhancing effect, thereby changing the inherent packaging integrity of cholesterol, phospholipids and proteins, thereby affecting the fluidity of the membrane.
 

Pukang SNAC Technology

 
Refer to SNAC excipients mechanism, we have some research. Semaglutide molecules are amphiphilic, and they can combine with each other through hydrophobic interactions to form oligomers. After semaglutide tablets are dissolved, SNAC the powder one can cause a change in the polarity of the solution and weaken the hydrophobic interaction between molecules. SNAC is lipophilic and can be effectively inserted into the upper cortical membrane of the stomach, which is penetration enhancing effect, thereby changing the inherent packaging integrity of cholesterol, phospholipids and proteins, thereby affecting the fluidity of the membrane.

Pukang Service For SNAC

Other Pukang Biological Products

CAS:1662688-20-1

Molecular Weight: 1196.51

Molecular Formula:C64H101N5O16

Appearance: Yellowish liquid

Application: medical intermediate

Delivery Time: Available goods in stock

Package: inside: glass bottle   outside: paper drum

Port: any port in China

Production Capacity: more than 20kg

Purity: ≥99%,single impurity:≤0.3%

isomer≤0.15%

Storage: store at under -20°C

Transportation: CIF by air or DAP by courier, FOB, EX W Etc...

0
0

CAS:1118767-16-0

Molecular Weight: 846.1

Molecular Formula:C43H79N3O13

Appearance: Yellow liquid

Application: medical intermediate

Delivery Time: Available goods in stock​

Package: inside: glass bottle   outside: paper drum

Port: any port in China

Production Capacity: more than 10kg

Purity: ≥98%,single impurity:≤0.3%

isomer≤0.1%

Storage: store at under-20°C

Transportation: CIF by air or DAP by courier, FOB, EX W Etc...

 

0
0

CAS:1169630-40-3

Molecular Weight: 830.97

Purity: ≥90%,single impurity:≤0.3%(except acid)

           isomer:≤0.1%

Storage: store at under-20°C

Transportation: CIF by air or DAP by courier, FOB, EX W Etc...

CMC documents has been completed according to CTD format 3.2.S API format

0
0

CAS:843666-40-0

Molecular Weight: 370.57

Molecular Formula:C22H42O4

Appearance: white to off-white powder

Application: medical intermediate

Delivery Time: Available goods in stock​

Package: inside: double PE bags  outside: paper drum

Port: any port in China

Production Capacity: more than 50kg

Purity: ≥98%

Storage: store at 2-8°C

Transportation: CIF by air or DAP by courier, FOB, EX W Etc...

 

0
0

CAS:1143516-05-5

Molecular Weight: 308.33

Molecular formula:C12H24N2O7

Appearance: white to off-white powder

Application: medical intermediate

Delivery Time: Available goods in stock​

Package: inside: double PE bag outside: paper drum

Port: any port in China

Production Capacity: more than 100kg

Purity: ≥99%,single impurity:≤0.5%

Storage: store at 2-8°C

Transportation: CIF by air or DAP by courier, FOB, EX W Etc...

0
0
About Us
Chengdu Pukang has a professional R&D team with rich experience, and innovative ideas, which can meet the various needs of customers from custom synthesis to mass production.
Contact Us
​​​​​​​​​​​​​​No.288 of North Rongtai Avenue,WenJiang district 611137,Chengdu Sichuan
Province,China.
+86-28-63976226
Copyright © 2021 chengdu Pukang Biological Technology Co., Ltd.  Support By Leadong  Sitemap / Private Policy
Leave a Message
Contact us