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SNAC-

SNAC Semaglutide Tablets Absorption Enhancer

SNAC is the absorption enhancer of semaglutide tablets. It is an N-acetylated amino acid derivative synthesized from salicylic acid, which is weakly acidic and amphiphilic. 
SNAC is the only penetration enhancer approved to improve oral absorption. In other preclinical studies, SNAC has the effect of improving the penetration of peptides (such as insulin) in the intestine. 
Semaglutide tablets containing SNAC are placed in different volumes of simulated gastric juice, and the pH value gradually changes from acidic to neutral. The smaller the volume, the more obvious the buffering effect; on the contrary, the SNAC-free Semaglutide tablets have no significant effect on the pH value of simulated gastric juice .In view of the significant buffering effect of SNAC, the effect of pH on the stability of semaglutide was investigated in in the presence of pepsin.
As the SNAC Manufacturer, we Chengdu Pukang can provide the high purity product.

Advanced SNAC Excipients Mechanism

 
Refer to SNAC excipients mechanism, we have some research. Semaglutide molecules are amphiphilic, and they can combine with each other through hydrophobic interactions to form oligomers. After semaglutide tablets are dissolved, SNAC the powder one can cause a change in the polarity of the solution and weaken the hydrophobic interaction between molecules. SNAC is lipophilic and can be effectively inserted into the upper cortical membrane of the stomach, which is penetration enhancing effect, thereby changing the inherent packaging integrity of cholesterol, phospholipids and proteins, thereby affecting the fluidity of the membrane.
 

Pukang SNAC Technology

 
Refer to SNAC excipients mechanism, we have some research. Semaglutide molecules are amphiphilic, and they can combine with each other through hydrophobic interactions to form oligomers. After semaglutide tablets are dissolved, SNAC the powder one can cause a change in the polarity of the solution and weaken the hydrophobic interaction between molecules. SNAC is lipophilic and can be effectively inserted into the upper cortical membrane of the stomach, which is penetration enhancing effect, thereby changing the inherent packaging integrity of cholesterol, phospholipids and proteins, thereby affecting the fluidity of the membrane.

Pukang Service For SNAC

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