What is the role of Cbz-PEG?

Polyethylene glycol, abbreviated as Cbz-PEG, is a pharmaceutical intermediate. What are the effects of drugs developed with Cbz-PEG as a raw material? Here are some of them.

Here is the list of contents.

l Hypoglycemic effect

l Protective effects

l Anti-cancer effects

l Surfactants

Hypoglycemic effect

Type II diabetes is a group of complex metabolic disorders whose pathogenesis is only partially known. It includes varying degrees of reduced pancreatic beta-cell function, peripheral tissue insulin resistance, and abnormal hepatic glucagon metabolism. glycemic control in type II diabetes tends to deteriorate progressively over time; when dietary control and exercise therapy fail, a new glucose-lowering drug intervention is required on average every 3-4 years to achieve or maintain good glycemic control.

A drug made from bioavailability stable Cbz-PEG can effectively lower blood glucose. Its main mechanisms of action include improving glucose uptake and utilization by peripheral tissues (e.g. muscle, fat), which can reduce excessive hepatic glucose output by inhibiting gluconeogenesis and glycogenolysis. In addition, this drug reduces the rate of fatty acid oxidation, improves glucose utilization, improves insulin sensitivity, and reduces insulin resistance.

Protective effects

Chemically, anticonvulsant drug eco-friendly Cbz-PEG is a polyether with a chemical structure similar to that of an ether, called ether, which is afraid of oxygen. In the presence of UV light and traces of metals highly reactive hydroperoxides are formed, and chemists are aware of the potentially explosive nature of ethers. This is why it is recommended to keep Cbz-PEG in the dark and protect it by adding antioxidants and chelating agents to resist oxidation by atmospheric oxygen. The complexing agents EDTA and phytic acid both quench the oxidation of trace amounts of metallic iron compounds. They do not require protection because hydroperoxides are formed only when combined with atmospheric oxygen, and this hydroperoxide can aggravate acne. Therefore, do not expose products containing Cbz-PEG to direct sunlight after use, when hydroperoxides may be formed. In addition to UV rays and trace heavy metals, heating also accelerates the formation of oxidation products.

Anti-cancer effects

The results of animal studies suggest that PEG-based drugs may also play a role in cancer prevention. Studies involving rodents have confirmed its protective effect against carcinogens. In addition, the compound can approach tumors through blood vessels. This property makes PEG-based drugs efficacious in controlling tumor growth, especially when they are not accessible by conventional imaging chemicals.

Surfactants

One of the main roles of organic chemistry hydrophilic Cbz-PEG is to act as a solvent or surfactant, helping to homogenize and mix chemically different components. In addition, Cbz-PEG interacts strongly with water, so adding Cbz-PEG to these products helps to keep them moist. In addition, some household products require a certain viscosity, and this is where Cbz-PEG comes in handy.

Chengdu PuKang Biotechnology Co., Ltd reminds you that Cbz-PEG is a very important pharmaceutical ingredient. Our company has a professional R&D team and senior after-sales service so that you can purchase our products without worries. We are very much looking forward to your contact.