What is the industry outlook for Cbz-PEG?

Cbz-PEG is by far the lowest level of absorption by proteins and cells among known polymers. Cbz-PEG is easily soluble in water, ethanol, and most common solvents at room temperature, and is non-toxic, non-harmful, and non-irritating to humans, and has good biocompatibility. Next is an introduction to the future of the bioavailability stable Cbz-PEG industry.

Here is the content list:

l Introduction to diabetes mellitus

l Pre-application

l Industry trends

Introduction to diabetes mellitus

Diabetes is a series of metabolic disorders such as sugar, protein, fat, water, and electrolytes caused by genetic factors, immune disorders, microbial infections, and their toxins, free radical toxins, psychological factors, and other pathogenic factors that cause hypoglycemia and insulin resistance in the body. The conventional diabetes treatment is drug therapy, and drug therapy is the most common diabetes treatment, and new glucose-lowering drugs made from Cbz-PEG can be taken to treat diabetes. The following diabetic patients cannot take new glucose-lowering drugs made from Cbz-PEG: type 1 diabetic patients (insulin-dependent), pregnant women, patients with significant liver and kidney dysfunction, patients who are unable to control blood sugar well despite taking a large number of hypoglycemic drugs, patients with severe to systemic or local infections, and major stressful situations such as major surgery, severe trauma, and long-term fasting cannot be taken either. What is needed is that patients who are allergic to oral drugs or cannot tolerate their side effects cannot continue to take them.

Pre-application

Polyethylene glocalization is the world's most advanced technology for pharmaceutical molecular modification and drug delivery. When pharmaceuticals non-toxic 98% Cbz-PEG derivatives are coupled to the surface of drug molecules, it will significantly enhance or change the hydrophilicity, volume, molecular weight, spatial conformation, and spatial resistance of molecular interaction of drug molecules, which can change the solubility of drug molecules, form a spatial barrier to reduce enzymatic digestion, with the outstanding advantages of reducing toxicity, lowering immunogenicity, prolonging half-life, changing tissue distribution to increase the concentration of target sites, etc. It is the mainstream drug longevity solution. Meanwhile, due to its excellent biocompatibility and hydrophilicity, it can improve the cytocompatibility of copolymer polymer materials and has great potential for controlled drug release and the reprinting of novel biologics such as proteins, peptides, and oligonucleotides.

The earliest and most frequent application of polyethylene glocalization is in the long-acting of protein or peptide drugs. In addition to peptide and protein drugs, it is also used in small molecule drugs and gene drugs to improve drug effect, prolong half-life, reduce toxicity, change the affinity of the target site, improve solubility, the realization of injectables, change membrane penetration characteristics, reduce immune response, reduce drug metabolism rate, etc.

Industry trends

In recent years, the incidence of diabetes and asthma has been increasing and the demand for new glucose-lowering drugs made from organic chemistry hydrophilic Cbz-PEG has been growing. The reduction of the relevant drug tax rate to zero is conducive to further reducing the burden of patients with drugs while encouraging domestic pharmaceutical enterprises to research and development production. Some industry insiders believe that as early as May 1, 2018, China reduced the import tariffs of all generic drugs, including anticancer drugs, alkaloid drugs with anticancer effects, and proprietary Chinese medicines with actual imports to zero by way of provisional tariff rate. This tariff reduction also reflects the gradual process of advancing from anti-cancer drugs, rare disease drugs to common disease drugs.

Chengdu Pukang Biotechnology Co., Ltd has used Cbz-PEG as the raw material for many of its drugs.