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Overview and assays for long-acting side-chain molecular block libraries
As biotechnology and peptide synthesis technologies become more sophisticated, more and more Long-acting side-chain molecular block library drugs are being developed and used in clinical practice. Long-acting side-chain molecular block library drugs are now widely used in the prevention, diagnosis, and treatment of tumors, hepatitis, diabetes, and AIDS, and have great potential for development due to their broad indications, high safety, and significant efficacy. The next section provides an overview of the research innovative powder and its detection methods. Here are some answers.
Here is the content list:
l Overview of the Long-acting side-chain molecular block library.
l Long-acting side-chain molecular block library drugs can be detected by
Overview of the Long-acting side-chain molecular block library.
Peptides are compounds formed by linking multiple amino acids through peptide bonds, usually consisting of 10 to 100 amino acid molecules, which are linked in the same way as proteins and have a relative molecular mass of less than 10,000. They play an important role in life activities. In recent years, the synthesis of Long-acting side-chain molecular block library drugs using modern biotechnology has become one of the hot spots in drug development.
Long-acting side-chain molecular block library drugs can be detected by
Reversed-phase high-performance liquid chromatography
High-performance liquid chromatography (HPLC) has become the most common method for drug quality analysis, which is sensitive, accurate, and fast. The analysis of substances in the Long-acting side-chain molecular block library is now mostly carried out by HPLC.
In addition to the traditional high-performance liquid chromatography, capillary electrophoresis for the analysis of the biological compound 98% drug long-acting crystal also has greater advantages, capillary electrophoresis has the advantages of both high-pressure electrophoresis and liquid chromatography, different from the hydrophobic separation mechanism of reversed-phase high-performance liquid chromatography, it is characterized by high analytical speed, high resolution, low sample usage, easy operation, and low consumption.
High-performance liquid chromatography-mass spectrometry
MS is a powerful tool for structural analysis, providing more information for structural characterization, and as an ideal chromatographic detector, it is not only specific but also has a high detection sensitivity. When analyzing substances with a Long-acting side-chain molecular block library by liquid mass spectrometry, it is possible to obtain the molecular weight and sequence information of the impurity without obtaining the pure impurity, and thus provide a basis for the characterization and structural analysis of the peptide in question.
High-performance molecular exclusion chromatography
High-performance molecular chromatography is a liquid chromatography technique based on molecular size, commonly used for the determination of the molecular weight of proteins and peptides, the determination of biomolecular polymers and molecular weight distribution, and the determination of macromolecular impurities in Organic chemistry hydrophilic clinic low side effects solution.
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